Busch, 35, drives for Haas' Nascar team, and this year he will try his hand at single-seater racing, driving for former F1 driver Michael Andretti's team at the fabled Indy 500.
But the Associated Press has quoted him as ruling out a F1 foray, despite his close ties to Haas.
"My time has passed to be a competitive driver in F1," he said. "But a test session? I'd jump on that every time."
Busch warned that Haas is "serious" about his new F1 adventure.
"You just don't drop $40 million on a wind tunnel and not think that you're serious about racing," he said.
"It will be an incredible challenge. He knows that," Busch added.
"We've had Michael Andretti, before him was his dad. We had Scott Speed as a driver. Now we have an (American) owner. It will be interesting to see how the driver lineup shapes up."